I have a cMP 4,1 converted to 5,1 and happily running Mojave for several years. It has a Radeon RX 580 graphics card driving the above monitor from its DVI port and also 2 x 20" ACDs from the 2 mini DisplayPorts, via active adapters. This has been working fine for years.
Recently, when waking...
I have an ATI 5870 that was flashed so I got a boot screen. I've had it for probably three years running on my Mac Pro 3,1. A week or two ago I bought a 30" ACD to replace one of the two 23" ACDs I've been running on it, both displays being run off the DVI ports on the card. I have a third...