I have a 5.1 Mac Pro tower...running 10.13.6 on an SSD out of my broken Imac and 10.14x on a 2 TB PCI drive, Radeon RX 580 8g, internal drives are the 512 apple ssd, 2tb crucial, 2tb 7200rpm and a 6tb 7200rpm....it will only boot 3 of the 4 drives in trays...and it does this in both operating...