A USB3 (type A connector) external case that specifically supports UASP (USB attached SCSI Protocol) should yield reads around 430mbps and writes between 250-350mbps (write speeds depend on the drive size, mfr, model). This will be roughly 3-4x times faster than booting and running from an internal HDD.
I'm thinking you could put a standard SATA 2.5" SSD into a USB-c/USB3.1 Gen.2 enclosure (which I -think- will support speeds up to 10gbps), and get even faster read/write speeds. But these enclosures cost more.
I predict that both you and your parents will be very pleased with a standard USB3 external booter -- and even more pleased with USB3.1 Gen.2.
Personal experience:
I've been booting and running my late-2012 Mac Mini from an SSD mounted in a USB3/SATA dock for going on FIVE YEARS now. It boots quickly and runs great. No performance degradations at all -- performs as well today as it did on day one.
Again -- just get them accustomed to the concept of "an external boot drive" vis-a-vis the "internal drive", and they'll be fine.
Last word:
DON'T bother with thunderbolt.
USB3 or 3.1 Gen. 2 is "all you need". See my personal experience above once more...