For info, Radeon VII is supported natively in Mojave 10.14.6. Therefore, no need to go Catalina or higher (if OP prefer that).
It also means OP can boot with Radeon VII natively without any boot loader / patched macOS (same as the RX580).
The Pro Vega II for the 7,1 is the "full version" of the Radeon VII indeed (64 cores vs 60 cores). So, driver support should not be a problem.
In fact, accrording to Apple's official page. Radeon VII is one of the supported aftermarket graphic card.
Learn which built-in and aftermarket graphics cards work with Final Cut Pro, Motion, and Compressor on Mac.
support.apple.com
For boot screen, there is no need to buy flashed card anymore. We flash the 6000 series card because they can't boot on the cMP by default due to incompatible UEFI firmware, but not due to boot screen.
OpenCore team already gave us the EnableGOP drive to inject in the cMP's bootROM, so that we can enjoy native boot screen (including hold option key to boot, or use firmware password) for almost any moden graphic card (inlcuding Radeon VII, 5700, and 6800). Even though that boot screen may shows artefacts with Radeon VII (so far, only Radeon VII has this issue), but it's totally usable (I am the internal tester on this matter). And use EnableGopDirect with OpenCore boot picker can show flawless boot screen even with Radeon VII.
In fact, Syncretic also created another bootROM patch for cMP, which also allow modern graphic cards to show native boot screen. But that's internal beta at this moment. With this cMP bootROM patch, there will be no need to patch the 6800 anymore, just plug and play on the cMP.
Dual Radeon VII can work, DV should able to fully utilise both cards quite well. But I highly recommend you downvolt the cards. Radeon VII by default can draw up to ~300W. On cMP, run 2x Radeon VII + 2x X5690 can stress the PSU to the limit (assume Pixlas mod already done, otherwise, no way to power 2x Radeon VII internally).
By considering we can downvolt a Radeon VII to save ~70W with virtually no performance penalty. 2x Radeon VII can save ~150W in total, which gives a 980W PSU an extra 15% buffer. Also, both GPU will run at a much lower temperature. I believe this can highly increase stability for long run.
Just upgraded from RX580 to Radeon VII (it's just $350 from a local seller, like new condition, with 2 years+ warranty. I really can't skip it :D) Anyway, as usual, all AMD GPU are seriously overvolted from factory (Default setting in Wattman shows 1801MHz @1093mV). Properly downvolt the card...
forums.macrumors.com
Anyway, I am NOT saying the Radoen VII is the best option for you. I leave it for you to decide. I just give you the extra info about Radeon VII.