I am running a 30" ACD and a 256mb MacbookPro 2.33, and it
cannot handle running Expose and Front Row at 60fps @ 2560x1600. It gets
VERY choppy... but there is a fix.
How do you fix this? The problem is that unlike windows, OSX has this thing called "Beam (or Vertical) Sync" which tries to render every frame of animations within the operating system at the LCD monitor's refresh rate (60hz). You can read a bit further here:
http://en.wikipedia.org/wiki/Vertical_sync
When the graphics card is incapable of rendering it at 60fps (frames per second), OSX tells the videocard to cut the frame rate of the animation down to a multiple of the refresh rate - 30fps. So then you get choppy animations.
Luckily, Beam Sync can be disabled. Read this link for instructions:
http://www.macosxhints.com/article.php?story=20050518113854620
So, if our X1600s are capable of rendering Expose at 45fps, we will see all 45 frames, even though we may get some tearing (a result of incorrect syncrhonisation of video data and the monitor refresh rate), but it's much less annoying than a choppy expose.
So yes,
running 2560x1600 WILL HEAVILY tax your video card, and you will need all the video "punch" that you can get. So definitely get the 256.