It's not a fitment problem per se, it's just 2mm more than the standard length-wise and you can always relocate the PCIe fan, the main problem is no drivers for macOS at all and how to power it since it uses the new 12 pin power connector. Btw, most models, if not all, will completely block the PCIe slot-2 since the cards are 3-slots wide.
You will have to find a way to power the card, needs to be feed by a dual Pixla's mod, and it will only run Windows 10 or Linux (when the drivers are released for Linux).
Btw, did you ever thought about the bottleneck that the Westmere Xeon and PCIe 2.0 will be to run such a card? For sure, someone will make it work with a MP5,1 running Windows 10 overcoming the oversize and the 350W power requirement, but it will make any real sense at all?