I have a Late 2015 iMac 27" 5K with an external USB 3 SSD drive I use for the boot drive.
I installed the macOS 10.15.6 update this morning, it installed successfully and rebooted, after that I noticed Safari and Mail had quit unexpectedly (and Finder did not show the normal crash dialog) so I decided to reboot, and now it will not boot and quickly displays the Apple logo then a circle with a line through it. Tried PRAM and SMC reset, rebooted into recovery mode and ran disk utility first aid on it and found nothing wrong.
I installed the macOS 10.15.6 update this morning, it installed successfully and rebooted, after that I noticed Safari and Mail had quit unexpectedly (and Finder did not show the normal crash dialog) so I decided to reboot, and now it will not boot and quickly displays the Apple logo then a circle with a line through it. Tried PRAM and SMC reset, rebooted into recovery mode and ran disk utility first aid on it and found nothing wrong.