Certainly
My main camera is the venerable E1, and I also have an IR-converted E330.
Of course, the camera body is not what takes the picture - the lens does.
I use the typical set of 14-54, 50-200, and 50 2.0 macro (soon will have the 7-14).
Nikon and Canon are certainly well-entrenched (and I do like many of Nikon's offerings - both lenses and bodies). However, I believe that Olympus lenses are unbeatable right now in terms of price/performance. They are also designed with 4/3 sensor in mind, and do not come in legacy focal length ranges.
Nikon do make a few nice DX-format lenses, but most of them are way more expensive than Oly equivalents. Oly 14-54 is about $400. Largely equivalent Nikon 17-55 is more than $1000, and it is not even weather-sealed like the Oly. This is the most dramatic example, but you get the idea.
Then there are a few Oly-unique features that I really like for my purposes. Effective dust elimination system is one. Focus by wire is another (I know some people do not like it, but I love it on my 50 mm macro). Of course, the 4/3 system weighs less than other systems based on legacy 35 mm lenses.
Now that the E3 is coming out, upgrading to that new body is a no-brainer for me.