I use iTunes Desktop Sync because of my particular musical interests and devices.
I'm a classical music fan (and jazz to a lesser extent) and much of my iTunes Library is derived from CD rips. In fact, I have two iTunes libraries, one is lossy, the other is lossless AAC. I also have three devices: an iPhone, an iPad and a moldy old iPod classic 160GB. The latter gets the lossless AAC files.
Due to the classical music (and jazz) marketplace, I can get superb classical music performances from the local library or used CD stores like SecondSpin.com. This allows me to rip lossless copies. Using iTunes Match, I can upload lossy copies and often get matched iTunes Store copies which are better than my own rips. Note that if I am buying used classical CDs, they are often a fraction of the cost of downloadable iTunes Store albums.
Also, the local classical music radio station has a free Download of the Week song. Even if I don't like everything, maybe 30 or so are worth keeping every year. These are typically ordinary 192KB MP3s, maybe 256KB, but if I upload to iTunes Match, delete the local file, then re-download, often I get a 256KB "Mastered for iTunes" AAC. That's a $1.29 value per song, so the value of these new tracks is $38.70 versus the iTunes Match cost of $20. It makes more sense for me to keep using iTunes Match.
Stores like SecondSpin are a godsend to those of us who care about access to inexpensive lossless audio tracks. Someday this may change, but not tomorrow.