I have never attempted this, but can Applications / Programs such as MS Office & Adobie CS5 be kept on a separate HDD instead of the OS HDD? Might be a dumb question, but I have to ask. lol
Uhhh, no - an application should never write anything to an application bundle. That would risk being rejected from the App Store and possibly break code signing. There is a standard API for application preferences, which are normally kept in the user's ~/Library/Preferences folder.A well-mannered application is supposed to store the app's preferences in the application bundle (what appears as an application in the Finder) so a good app should keep its preferences when you move it to another drive.
Also I see that the path should be: ~/Library/Containers/com.Appname/Data/preferences/com.Appname.plist
the "~/" meaning relative to the current user's directory, not an absolute path, right?