I have Settings, Calendar, Photos and Camera across the top of my first page; those never change. The rest of the first page has my frequently used apps (Facebook, TwitterFon, etc). Second page is "info" apps (Wikipanion, SportsTap, Fandango, USA Today, plus FML and TFLN). Third is multimedia stuff (Photogene, Flickr, Pandora, NIN Access). Fourth is least used but non-native apps (games and things like Bump, stuff I only use on occasion). Last is least used native apps (Calculator, Stocks, YouTube, etc).
I get bored easily, so I rearrange a lot. Until today I had each page with only three rows full, and three apps in the dock. Just today I discovered a site through this forum that lets you create blank bookmark icons so you can space out your apps. I had a lot of fun with that.