I'm not sure why the other poster is having problems playing HB encoded files in QuickTime. Mine play just fine.
Same here, never had a problem.
Like many have said, just try a few tweaks and see what you like best. I used to do a two-pass customized setting but for the last few months I've just gone with the stock AppleTV setting and have been happy with it.
Some advice though and I ALWAYS do this step now. It's a pain but it's worth it and you'll understand if you do any Disney films from the last year.
BEFORE opening the movie in Handbrake, open it first in DVD Player.app, go into the actual movie (any chapter, doesn't matter) and right click to determine the Title it's using. Close it out and select this Title in Handbrake.
Here's a few reasons why.
1) If the movie contains both Rated and Unrated versions, this way you'll get the one you want.
2) Disney now includes 99 Titles (literally). Only one of them is correct and the others are all jumbled messes of the movie.
3) I've had some movies with a few titles that all seem to be the correct length and HB doesn't know which one is right. If it selects the wrong one you get a movie thats about 4 minutes longer because the opening 4 minutes gets played twice. I have no idea why. But it's annoying when you start watching a movie you ripped and a few minutes into it just starts over. Pineapple Express is an example if I remember correctly.
Save yourself a little headache and use DVD Player.app to determine the "real" Title.
Good luck!
Edit: Thanks spice weasel. iDVD.....that would just be stupid
