Hmmm, I didn't have that problem, but I have a 21.5" iMac with 1920x1080.
My Wacom Bamboo worked better by
not installing the accompanying CD --and downloading the latest Drivers from the Wacom site directly. A BIG difference in the way the pen responded. (Wacom is notorious for buggy drivers apparently.) In fact, I had to do a Search & Destroy to remove all traces of Wacom-anything from my iMac, then download the newest driver from the Wacom site. HUGE improvement. But yours is the very newest Bamboo tablet, it may be a lot better out of the gate.
Pixelmator is still priced at $29.99 in the MAS. It looks and feels more native to Mac than PhotoShop. You'll probably be happier with that than PhotoShop. Every time I open Pixelmator I feel like I've poked Adobe in the nose.