With all of the other settings maxed out (except FXAA is off and physx is low), I was able to get 20fps out of 2880x1800. It looked really crisp, but it wasn't the most playable. The next resolution down that Borderlands 2 supports that fits the screen is 1900x1200. The game plays with FXAA on in that resolution at about 40fps. That is a lot more playable and the game still looks really great.