Running Photoshop CS6 via Wine on macOS Ventura might be technically possible, but it can be very unreliable. Wine doesn't fully support all features of Photoshop, especially for complex or resource-heavy tasks. You'll likely run into issues with performance, compatibility, and even basic functionality like font rendering or GPU acceleration. Additionally, Photoshop CS6 is outdated, and Wine might not handle it well on newer macOS versions like Ventura. Your best bet is to either upgrade to a newer version of Photoshop or run the Windows version in a virtual machine (e.g., Parallels) for more stability.