Yep, I've got Civ5 on my 2012 i7 Mini with 8GB RAM and Fusion Drive. I haven't played it much so can't give you a detailed account but it was certainly playable at 1920x1080 with middling settings. It depends a lot on exactly how far out of the map you zoom, it does begin to stutter if you zoom out a long way. I never had any problems that limited playbility. Perhaps if you got loads of units on the screen it might slow down more.