Before you put in 16 GB of NuRAM, you might want to do some reading and searching to make sure you're wanting to do this.
The jury's still out as to what is causing the problem, but the number "16 GB" and the name "NuRAM" keep cropping up.
Here is one thread about it:
http://discussions.apple.com/thread.jspa?threadID=2548180
Everybody doesn't have the problem, and although OWC are watching the reports, and freely doing an RMA if you buy 16 GB of NuRAM and have this problem, nobody knows yet what the problem computers all have in common.
It seems so far that the people who've replaced the NuRAM with Samsung are saying they no longer have the issue. I have taken the extra precaution and gone down to 12 GB of Samsung, and the NuRAM is packed up, ready to go back.
Some people are also claiming that it's only the people who are starting the 64 bit kernel consistently are the people having the problem. One of the things I tried, however, before deciding to get away from NuRAM was starting with the 32 bit kernel and I had a shutdown while using Safari and a java rich page.