I own two Drobo 4-bay enclosures. One I've had for two years, the other for 11 months. Currently, I have four 3TB WD Caviar Green drives in each. They're connected to my Mac mini via FW800, the 2nd Drobo daisy-chained to the 1st. To date, I have had zero problems with either array. No random rebooting, no corrupting of data. I moved from 1TB to 2TB to 3TB drives on both arrays with no issues (other than the eternity it takes to redistribute the data across the drives). FireWire works as it should, although my read write speeds are still quite poor (~31MB/s). The speed problem has likely been addressed with the 5D. With 7200rpm drives the unit was audible, but after switching to 5400rpm Caviar Green drives the sound levels became a non-issue for me.
I only paid $199/ea for my Drobos, which is less than comparable 4-bay solutions. I feel like I've gotten my money's worth. Shelling out $850 for an enclosure with no drives? Not so sure about that. Then again, I use mine for media storage only, so I don't need the fastest thing around.