Not sure if this is also true in macOS.
From AMD support page:
Connectivity Requirements: AMD Eyefinity technology is supported by graphics cards in the ATI Radeon™ HD 5400 series and higher. These cards can support up to six monitors (depending on the model), subject to the following restrictions:
• A maximum of 2 legacy monitors (VGA, DVI or HDMI) can be enabled simultaneously, provided that each monitor is connected either directly or via a “passive” DisplayPort™ adapter/dongle. “Passive” adapters/dongles will NOT support more than 2 legacy monitors.
• To enable support for more than 2 monitors, “active” DisplayPort™ adapters/dongles are required (or monitors with direct DisplayPort™ connectivity must be used).
• Approved “active” adapters have no general connectivity restrictions with AMD Eyefinity technology.
But AFAIK, some cMP users can drive three monitors via a single HD5770 with proper adaptor(s).