Hey, just installed it tonight and it ran fine.
Alu MacBook 2.0 4GB OWC Ram
I am using 32bit XP (TinyXP) so 2.7GB was recognized and I believe 512 was being used for VideoRam since XP does this some reason.
Anyway, before I started up the game it was able to find the hardware fine and recommended medium settings. BTW using all Bootcamp 2.1 drivers and have not messed with the nvidia driver at all. umm no anti aliasing and no something else, but HDR was on not sure what HDR is but I just left it at all recommended settings.
thoughts on how it runs: overall runs fine, medium looks great (I have ps3 version too, can't tell much difference) but I did notice some sluggish framerate at times, but not often. A few hiccups here and there mostly noticed at 10th Bday party I guess b/c of all the people in the room. I played through and got out of the vault no problem. I didn't feel like I was overloading the mac's hardware haha. When I mean sluggish definitely not slideshow, but more like 20fps or so probably, I don't know the command line to check out FPS but will check next time.
Also I have it on PS3 which I played 20 hours before stopping lol. I figured I'd rather play it on PC b/c of dlc and mods and shooting hipfire w/ the mouse is much better than relying on VATS all the time on the dualshock lol.
so we're pretty much in the same boat. You're safe, but I can't comment on securom that the retail disc has, not sure if that does anything differently w/ windows. Plus w/ TinyXP my windows boot is super fast since i have a bare min installation.
sorry for the grammar etc I'm tired and I'm just typing off the top of my head honestly. Which is why my thoughts are kind of...everywhere haha. Let me know if you have further questions, I'll be happy to answer it.