You won't like my advice, but I upgraded to High Sierra on my Fusion Drive by Migrating my data from backup. WRONG. Only this week have I realized that I should have wiped the fusion drive clean, then done a CLEAN install of High Sierra, and NO MIGRATION. Install fresh all apps from Apple or trusted vendors, then drag your personal document data from backup, but DO NOT MIGRATE. After regain the clean installed High Sierra Fusion Drive, all my issues went away.
And yes, there are now apps that have lost my settings in the clean install, but I have my backups and I will find these cache or plist files eventually. But the fusion drive runs as sold now.