I think you should be able to under Rosetta, if you're still running Snow Leopard. Your fans are going to roar most likely (I think this happened when I tried it). It's not because of the game, it's from the virtualization.
Best way I think would be under Paralles/Fusion/Bootcamp and using a Windows version.
I lost a lot of games switching to Mountain Lion but I think it's worth it. That, and I'm planning on buying a PowerMac G4 for gaming.