I used the harmony 550 for about a week with my mac mini before returning it. The harmony is capable of learning the apple remotes button presses. In addition, remote buddy allows the remote to control the mouse cursor. Only problem is...the harmony doesn't send the IR signals in a rapid, continous fashion so there was a considerable delay when holding down a button. I was unable to make it any quicker and decided to give up on it, it was just too painfully slow.