Put it this way, by setting up "activities" my wife now uses our home entertainment system with a single gripe. That in itself is absolutely amazing, she hates having to worry about more than one box at a time. Its the best remote out there - period. Be prepared to spend a bit of time tweaking the settings a bit if you're picky like me, or maybe adding a few tasks to the activities, but once its set up, Harmony remotes can't be beat.
My Apple remote now sits in the bag for my new Macbook, which didn't come with one.