Wear anti static band or even gloves.
Ground yourself (automatically done when you touch the cMP metal case).
Physically disconnect power from the wall.
Highly recommend move the cMP to outdoor area.
Open it up. Pull out the CPU tray. Use a duster (
like this one) to clean it. No need to go too extreme. Just blow out most very obvious dust is good enough.
For "deep cleaning", you may take out the GPU and PSU for better clean.
When cleaning a blower type graphic card. Blow from the exhaust will push the dust coming out from the front.
For PSU. If very dusty, you have to take it out for a good blow. But for normal cleaning, just open the optical cage, and apply good blow back and forth a few times usually good enough.
IF you applied COMPRESSED AIR. It is recommended you wait for something like 30min before you put everything together again and power it up. But for duster, there should be no moisture, and I clean my cMP every 1-2 week. Always power it up straight away after cleaning. No problem at all.