I lose all my cydia tweaks after respringing or rebooting help me
Don't you have any backup of your files?
yes, Reboot it again!!
I agree with all, if you want more appropriate answer tell us the iOS details.
im on 6.1 iphone 5 evasion jailbreak
What are your tweaks?
I ask because I just downloaded nospot and have had some of my Cydia apps disappear although Cydia shows them as being installed under sources.
I ran into a similar issue when I decided to test out semirestore and iLex R.A.T.
I tried many possible fixes but what appears to work is re-jailbreaking with the latest version of evasi0n. Then also re-installing mobile substrate was a good move.