@tjnewt did you ever have any success with this?
I just did such an installation on Saturday. I have never had trouble installing any version of Windows 10 on my 5,1.
Use a destination drive that is connected to one of the onboard SATA ports; it can be either a spinning hard drive or a SATA SSD. To boot from the install DVD, hold the Alt (also called Option) key after you hear the startup chime and then
do not choose the EFI installer. The legacy installation should work great.
The installer might take a very long time to boot and might look like it's hung for 15–20 minutes, but don't let this scare you. Let the system sit until the installer starts.
The last release of 5,1 Mac Pro boot camp drivers does not fully support Windows 10, so you will need to use the iMac Pro Boot Camp drivers. You can use the Brigadier app to obtain these. See the first post of this thread for information and some additional direction:
Note to mods: This is not iMac Pro intended, but Mac Pro 5,1 Since Apple is not releasing BootCamp for MP5,1 anymore and we are forced to use iMac Pro BootCamp drivers to have APFS support, I thought that a thread tracking iMac Pro BootCamp releases, with the direct link for the current one...
forums.macrumors.com
Windows Update works fine and will offer to install drivers for certain hardware, though I did need to update my graphics card drivers separately by downloading them from AMD. (Windows Update insisted that it could install a newer driver, but the driver offered by Windows Update was actually much older than the version I downloaded from AMD.)
Good luck and let us know how it goes.