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I use LR on the 2021 12.9 but I would think that it should work fine on the new Mini - I used it on earlier iPads. The only downside is the screen size but that's only my bias toward wanting larger displays for photo work, one of the reasons I went with the 12.9.
 
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I wouldn’t be happy with the screen size for photo editing long term but that’s probably personal preference.
 
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I think a larger screen would work better for Lightroom. Looking forward to using my mini as a hub between my camera and external SSD, though.
 
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