Freeway Express 5
I used Freeway Express 5 to make my site (see link below). I'm no coder either, and wanted something that was as easy to use but powerful enough to make a website as I wanted it to be. iWeb I found too basic and I didn't get on with the way Rapidweaver worked. Freeway works rather like a desktop publishing program, imo.
Freeway (£46), Fetch (£21) and TextEdit are my new best friends! I found the price of Freeway great for what it can do. Fetch I think is a little steep, but then again it works great. Cyberduck is a free ftp program but I had so many problems getting it to work I stumped up for Fetch and haven't looked back since. Both Freeway and Fetch offer 30 day fully functional trials.
There is a Pro version of Freeway too, which allows even more advanced functions, but I'm not that far into web design yet!