There was a Samsung 49" at 3840x1080, it's resolution is under 4K, but I don't own one, and haven't seen it sold as new for years.
I've got a Samsung G9 49", and PbP (Picture By Picture) mode works like two separate monitors. If your GPU can drive two 2560x1440 monitors, it can drive Samsung 5120x1440 in PbP mode too, it's essentially the same as two monitors.
I do own a Mac Pro 2,1 with GTX 680 4GB and a Samsung G9 49" 5120x1440, but they are at different locations right now, so I can't test this for you. I'm pretty sure you can get it to work IF your GPU is capable enough for the above mentioned resolutions (2x 2560x1440). You can use two GPUs too if you want to. Or you can hook up two different sources (different computers) even. I used to drive Mac Pro and Win HP Z4 side by side a few years ago.
And I think you'd want PbP, not PiP. PiP stands for floating small window in front of the bigger screen. PbP stands for two monitor views side by side. With Samsung they are sized identical 50x50%.
There are other monitors with different PbP ratios, like Dell 40" U4021QW, and you can divide it by 50x50%, 75x25%, 80x20%. This too works like two separate monitors, just without the frames in between.