I have a 5.1 Mac Pro tower...running 10.13.6 on an SSD out of my broken Imac and 10.14x on a 2 TB PCI drive, Radeon RX 580 8g, internal drives are the 512 apple ssd, 2tb crucial, 2tb 7200rpm and a 6tb 7200rpm....it will only boot 3 of the 4 drives in trays...and it does this in both operating systems....and it seems random on which will get booted. I've moved them around and done restarts, one of the two bigger Non SSD drives constantly won't spool up. It's not the ports as each one will work, but only 3 at a time. Not sure what to look at or do as a work around.