Just want someone with more knowledge than I to confirm there is no major down side to chaining thunderbolt 3 devices. Planning to daisychain two thunderbolt 3 disk arrays and one Thunderbolt 2 array as last item in the chain on one port and 1 4K monitor and 1 1440x2560 monitor on the other.
Depends upon the throughput speeds to/from the drive you are looking to get. If these are relatively low speed HDDs in modest numbers then there can be not much of a difference. If relatively high stripe width and in relatively high numbers ( > 10 ) then probably not the best path. Especially on a new Mac Pro where there are at least two pairs by default.
Pragmatically Thunderbolt ports are provisioned in pairs ( off of a Thunderbolt controller. Apple tends to essentially refer to that as a "Thunderbolt bus". ). If you hook the same set of drive arrays to the same TB "bus" then there really is not difference between
TB-bus-1 ---> TBv3_drive1 -> displayPort -> 2k_monitor
|----------> TBv3_drive2 -> TB_4K -> TBv3_to_v2_adapter -> TBv2_drive1
and what you proposed above. You aren't "speeding up" the TB drives by segregating them away from the the video much if they are just 2-4 HDD arrays.
If those were TBv3 SSD drive arrays which each are generating around x2 PCI-e v3 worth of concurrent same direction bandwidth demands then not just daisy chaining is ill advised, but putting them on the same TB "bus" would be too. ( putting on the adjacent port controlled by the same controller being feed through the same host PCI-e bus is a gating factor also).
One issue is that monitors are basically unidirectional but drives can be both direction. So if TBv3_drive2 is primarily being used for reading static source material (and TBv2-drive1 is something like TimeMachine backup ) then there isn't much impact of putting the outbound 4K data stream there ( TimeMachine is relatively slow and it is to a v2 drive anyway).
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Displays can use a different set of pins on the connector meaning they may not impact anything at all.
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That is not how Thunderbolt v3 works. Both display and PCI-e data streams are being sent over the same set of wires. The data is encoded and multiplexed. It is just bandwidth demands by the collection of the devices that primarily matters.
4K (and up) tend to be unidirectional hogs on outbound (from system) traffic. But inbound they are not a problem at all. Thunderbolt is also bidirectional. The bidirectional is on separate pins/wires.