2TB drives ship with later mac mini models though, and the case hasn't changed? (my 2011 model is the one without optical drive).
Which mini models have a 2TB single drive? I believe you'll find they're really 2 x 1TB.
i just read this thread, apparently it is possible.
https://forums.macrumors.com/posts/16007575/
You also have heat and power to contend with. I added an Intel SSD in mine and switched it to be the boot drive, and kept the stock 500GB for storage.
Even more storage? Thats what Thunderbolt, Firewire, and gigabit NAS is for.
from reading further in that thread, there is 9.5mm 2TB 2.5" drive - http://www.seagate.com/about/newsro...ivision-ships-2tb-storage-solution-pr-master/
Apparently people have been removing this 9.5mm 2tb drive from enclosure and installing it in laptops, game consoles etc.
http://www.amazon.com/Seagate-Backu...&qid=1403191473&sr=8-2&keywords=spinpoint+m9t
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I believe drive height is your limiting factor, not heat.
AFAIK you're not going to fit a 15mm drive into a 2011 mini and there are no 2TB 9.5mm drives. Max 9.5mm showing on Newegg.com is 1.5TB. Since 1.5TB is also listed at OWC, I'd say your max is 1.5TB at this time and that it likely will work fine (else I doubt OWC would sell it). See http://eshop.macsales.com/shop/mac-mini/