Warcraft 3 can be controlled completely by the mouse. There are tons of mods available. I use my thumb-button(assigned as the middle button) to pan the screen, which is easier than moving the mouse to each edge.
World of Goo. GREAT GAME!
All the old graphic adventures, like The Dig, Monkey Island, and so on. The can be played via SCUMM VM OS X. Most graphic adventures are mouse driven, the few that weren't I tried to avoid.
Have you played Fallout 1 or 2? I just picked up the trilogy and so far it can be worked with only the mouse that I know of. These games can be played via Bootcamp.
I'll try to think of some newer ones, but in recent years there's been a dry spell, as many developers were console happy and neglected the PC, but that seems to be passing now.