As far as setting them up it is as easy as setting up any other Base Station, maybe even easier. You can set them up as your main router, as an extender or even just as a client so you can use just the Airtunes or print server functions. I have an Extreme N Station as my main router. Then I have the 2 expresses set up to extend range and one not. They are all named for the rooms they are in. Then when you open iTunes on any computer on that network you will see a new window pop up at the bottom of itunes. YOu can then decide to play music through "Computer" any of the single expresses or select "Multiple Speakers" and that will open a separate dialogue box. Here you can select none, all or some. The cool thing I found out was separate computers can play to separate airtunes at the same time. So if I am in kitchen I can play music from my imac up stairs to the kitchen airtunes and my girlfriend can play music from the laptop to the airtunes in the bedroom. No tricks or anything .. its just that easy. YOu have to make sure if you have older expresses that you have your firmware up to date. It did not always do these things.
Kevin