yes. (as long as the sharing is set up properly in Windows, and, obviously, the Windows box is on). Across the network the file system is (mostly) irrelevant, as it's the host that does the interfacing on behalf of the network.
You should be able to pick up the PC in Finder>Network easy enough, or if that fails through "Connect to server" (apple-K) with smb://[pc ip address eg 192.168.0.10]/sharename.
Macs belong to the Windows workgroup "WORKGROUP" by default, but you can change that in Directory Access to match the PC's workgroup if it's something different. Enable Windows Sharing in the Sharing prefs if you want the PC to be able to see the mac.
You can even mount NTFS drives directly on X, but you can't write to them.