Genuinely baffling as by the picture it definitely looks like a hardware-side issue. I would still be intrigued on if booting the machine on either into internet recovery or an external drive if you have one spare shows the same results?
At least that should completely knock out any thought of some software issue.
My other thought was going to be - more so if this was an over time issue - that perhaps your environment could be very humid. The bottom corners are quite notorious in getting dust trapped in the display around those areas, same could be for water (which is what your spots remind me of).
I don’t think we’re looking at any type of over heating issue burning through to the screen as it would have to get through the whole backlight assembly layer first, plus that spot is whereabouts the speaker sits.
Honestly by what you’ve said this looks like a strange mystery to me..