Since the Apple Silicon Macs support Thunderbolt, they must also support PCIe and they must have the drivers for PCIe controllers such as USB, SATA, Ethernet, FireWire, etc.
Every GPU that macOS has a driver for might be usable with Apple Silicon. Apple just needs to recompile the drivers. Do they control the drivers, or does AMD? Check Big Sur. Are the kexts FAT binaries (with x86 and ARM images)?
The GPUs won't be usable during boot since they only have x86 code in their roms (separate BIOS and EFI images). However, any GPU that Apple has a driver for could have a boot time driver created by Apple in the firmware. Doesn't the Mac Pro have AMD boot drivers built into its firmware?
What's the boot environment for Apple Silicon Macs? Is it EFI? The EFI spec was originally created by Intel for Intel PCs. EFI byte code is an option when x86 code cannot be used. I haven't seen a GPU with EFI byte code yet though. I suppose Apple EFI could have an x86 translator. Before there was EFI, there was OpenFirmware. GPUs for Macs back then had OpenFirmware byte code.