These are the apps/drivers that I've been compiling from reports or my own experience that now require AVX/AVX2 and do not work, or work with serious issues, with MacPro5,1:
Audio related:
- A.O.M. Total Bundle
- ARC Studio
- MASSIVE X
- ModoDrum
- MDrummer
Video related:
- Adobe Premiere Pro 24.0
- Adobe Media Encoder 24.0
- C4D S26.1
- Corel Painter 2023 (several brushes do not work without AVX2)
- DisplayLink drivers
Photo editing and related apps:
The main issue is that after Monterey is declared obsolete, apps developers will start to remove workarounds for processors without AVX/AVX2 support, since Ventura/Sonoma now require AVX2.
This is not only a problem with Macs, Windows users are now having the same issue with low end processors that also do not support AVX/AVX2.