Well, it's not like this is the first generation of the OQO... it looks like a nice improvement all around, generally. Reviews of gen one from users and press alike said it was an interesting concept, but much more niche than the traditional space of ultraportables or subnotebooks (traditionally more like 1.5-3.0 lb notebooks with keyboards that are at least loosely amenable to touch typing).
I am very happy with the trade-down in size from my Apple notebook to my Eee, but I wouldn't go down from my Eee to an OQO for several reasons: (1) my phone -- a Blackberry -- or one of several other phones has a much more suited interface to walking around and thumbing; (2) The 7" screen I have right now is at the very lowest edge of size I'd consider usable for extended surfing of more than a few minutes; (3) I can type 70-80 wpm on my Eee and I don't see that happening on an OQO.
The OQO does have an excellent complement of features, though. It's very nice engineering work to have crammed all that -- WiFi, BT, 3G data services, etc, into that package.
But basically, I went from a 4.6 lb Apple notebook to a 2lb Asus, and I don't really miss having a bigger notebook (perhaps aside from the fact that I could probably use a few more gigs of flash storage, and also aside from the bugs with the current Asus product, none of which are inherent limits based on the size). I don't think I could trade my notebook in for the OQO and not miss my notebook, at which point it becomes another device in my briefcase instead of taking a device out and replacing it with something lighter.