I'm on lion right now and one of the things I find annoying is the fact that whatever type of scrolling you choose for the trackpad automatically applies to the mouse as well. I want to use natural scrolling for the trackpad since it's based on touch, but normal scrolling on a regular mouse because scrolling up to go down on a mouse isn't intuitive at all. Does ML allow you to separately dictate how the trackpad/mouse scrolling works?
It's been a while since his argument has come up. If you really stick to it, Natural scrolling, even on the scroll wheel, becaumes just what's it's named for. Natural. You're going to have to get used to it.
Scrolling direction is a system setting. It is the end all for interpretation from whatever device. I'm sure that they're could be a solution to your problem, but i doubt it's been coded yet.
That theoretical app would know what devices are plugged in, and if their a mouse or not. If it's a mouse, perhaps it could correct the scrolling for you.
Allthough, I've read some articles a while back about "Muti-mouse systems" where there would have been mutiple cursors on a windows screen. It never worked as far as i remember. Because the system only sees one mouse input.
Anyway, i hope i've been a little helpful. You might have to get used to it.
I know what you mean about mice but I don't think you can do it with OSX, there might be a 3rd party method but i don't know of it.
Technically he beat me too it because i was too busy writing more of an in depth answer then that simplistic reply.