I just picked up a Crumpler Dreadful, but I also have a Puma Messenger with an Incase sleeve and a Chrome Metropolis. Great bags, but I'm now partial to the Crumpler since it's new and it has a built-in padded compartment for my MBP. I'm also going to order a Crumpler camera case that fits inside the Dreadful to carry a camera body, a couple of lenses, a flash and accessories.
The Dreadful has tons of room which basically means the bag will be heavy when filled. At least it has a non-slip shoulder pad for comfort.