what version of 10.12 are you on? are there any OS updates waiting to be installed? otherwise, 2 things: create a test admin account, try it there. or reinstall the OS from recovery...
so a test account works; suggests that the problem is with your account. you could try this: close Preview, go to HOME>Library>Preferences, and delete com.apple.Preview.plist
reboot, see how that goes...
EDIT: found this on apple forums: (this is in your HOME library)
In Finder, open ~/Library/Containers (to open the hidden Containers folder, in Finder use Shift-Command-G and type ~/Library/Containers in the pop-up window)