I did the Sequoia release upgrade and my second monitor (using HDMI, primary is DP over USB3) wasn't recognized anymore (has been working for the last 5 years.) I tried unplugging and reinserting the HDMI on the display, restarting the Mac Pro and forcing display scan (option key in the display settings pane) but it wasn't recognized. I finally crawled under my desk and changed the HDMI port on the video card (base display, AMD Radeon Pro 580X 8 GB) and that resolved the issue (at least for now anyway.)
Hope this helps someone.
Hope this helps someone.