Become a MacRumors Supporter for $50/year with no ads, ability to filter front page stories, and private forums.
There is an OS X patch for it, but if I recall it had some bugs in 256 color mode in 10.6, so you have to run it in a window. You may be better off getting the gog.com version and playing it through crossover.
 
Wow I loved playing SMAC. Who knew that anyone else still did??

While I have made peace with playing Civ 5 on my 2007 iMac, I'd love to occasionally get a SMAC fix now and again.

If you get SMAC up and running, let us know how it works. Cheers.
 
Register on MacRumors! This sidebar will go away, and you'll see fewer ads.