Just wanted to +1 this. I just upgraded my iMac 27 2019 x86 to Monterey 12.2.1 from Catalina. I use a Synology DS1019+ running latest DSM for holding Vmware Fusion VMDK's for my various Windows VM's. The config is SMB2+Jumbo minimum and SMB3 max on the Synology. On the Mac side I'd not yet disabled signing required as it had never been an issue previously.
The VM's seemed sluggish immediately after upgrading and within a few days one had corrupted itself in a way that no longer lets it boot. Vmware Fusion tools could not repair. Windows DVD could not repair. I copy the VM to local storage using rsync over ssh to the synology since I'm not trusting SMB at this point. That at least let me install a new Windows over top to recover my files from Windows.old where it moves the prior OS install.
I start tinkering with settings, did some disk benchmarking, the performance is way off. My config uses the onboard gigE, but with jumbo frames and vlan virtual interfaces so my computer can be on my normal network plus a non-routed storage network where the Synology lives. The MTU is 9000 on the ethernet interface, 1500 on the primary vlan, 9000 on the storage vlan.
Tried to install a fresh Windows 10 VM, it fails at random parts in the process with disk I/O errors. The share will also go inaccessible at times. Tried the SMB signing thing, no change.
I connect a Thunderbolt to Ethernet adapter I had lying around and cable it into the second ethernet on my Synology, then go back to non-jumbo, and since it's dedicated, no vlan interfaces on top of the ethernet interface. The disk benchmarking tools return to normal performance in this configuration over SMB, but still seem to disconnect the share at times. I also still can't make it through a Windows install to an end product that ultimately boots, although it runs much quicker.
So it seems Monterey has tinkered with virtual interfaces in a performance impacting way, and SMB seems somewhat broken as well, to the point that file corruption results. Am continuing to play with it to see if I can find a working config, may reach out to Synology support. Am also going to do some more testing with other tools outside of vmware fusion to see if I can reproduce the corruption issue definitively.