For a single file on the disk image, the two formats are probably roughly similar. I can't think of any clear advantage one would have over the other.
Here's a summary explaining differences between the two formats:
en.wikipedia.org
The differences only become signficant when there are files on the disk image that are updated. Under that scenario, a sparseimage will show the entire single image file being modified, while a sparsebundle will only modify the 8MB bands which hold modified data.
An example can illustrate the significance of this. Suppose you have a disk image with 10 files. You add 1 file of 20 bytes. In a sparseimage, the diskimage file may grow slightly or stay the same size, but the entire diskimage file will be modified. So if you were to back it up, the backup app would need to read and write the entire file. Conversely, in a sparsebundle, only the 8MB band-files for the directory entries and the location of the data will be modified. A backup app will see at most 2 or 3 modified 8MB band-files, and only those will need to be copied to the backup media. Time Machine, for example, would use hard-links on all the band-files that were unchanged.
In the example you gave, which has a single file growing from 50MB to 75MB, both formats will grow from roughly 50MB of disk space to 75mB of disk space. The main difference will be in any backups of those diskimages. A sparse image will have a complete copy of the entire sparseimage file for every backup. A sparse bundle will have a complete copy only of the 8MB band-files that changed. If the file data is very different for each backup, then many or all the band-files will change, and a sparse bundle has no advantage over a sparse image. However, if the first 50MB of the file remains unchanged, then the sparsebundle's backups will only have the differences from the prior backups.
This may be affected by the format of the disk image, i.e. whether it's HFS+ or APFS. I'm not familiar with exactly how APFS expands the space allocation for a single file, so it might be worthwhile to do your own testing to see if there are any differences. That is, make sparseimage and sparsebundle in both HFS+ and APFS formats, then copy a 50MB example file to each. Grow the file to 75MB, and see what happens to the size of the diskimage.