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I'm guessing your talking about how to stop it from opening every time you log on, am I correct?

If so, I just checked the Preferences on Skype and there doesn't seem to be an option to load it on login or not. All I can say is, it doesn't open for me when I log on and I haven't changed any settings since having it.
 
To stop startup at login I had to remove Skype from the login items. Go to System Preferences/Accounts/Login Items. Then select Skype from the menu and push the minus sign that is under that menu.
 
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