After speaking directly with the folks at MacSales.com/OWC, I learned that the SATA interface present on the Samsung 860 EVO SSDs we're considering effectively "bottlenecks" (more or less) data transfer to a maximum rate of 6 GB/s ...so, in short, we can buy all of the Thunderbolt (TB) tech we want, but, as long as we're using SATA drives for storage, we'll never actually realize data transfers faster than 6 GB/s.
This being the case, we're going to start with an enclosure that supports the Samsung 2.5" SATA SSDs, but will not be using said enclosure with any TB interfaces (as mentioned in the original post). Instead, we'll buy an enclosure that comes with (2) FireWire 800 ports and (1) USB 3.1 Gen 1 port to use with the Samsung 860 EVOs. Yeah, the FireWire (FW) ports transfer data at a max of 800 MB/s, but that clearly outperforms the USB 2.0 ports on our present machine and the single USB 3.1 Gen 1 port -- at a transfer rate of 5GB/s -- puts us pretty close to the 6 GB/s ceiling we face with SATA transfer cap.
I realize that the thread was started with a question about durability of the latest 2.5" SSDs, but the fact that we're using the SSDs in an enclosure makes this added information important to those looking for the same kind of storage solution. No, we don't believe that SATA drives are going away any time soon, but we do believe that the Serial ATA (SATA) bus technology comes with certain limitations...which I assume NVMe will address in the future.
Regardless, any thoughts on the SATA limitation, and why we're thinking about it in this way, would be well received.