It depends on what type of mac you have and the specs, but yes they should be able to handle it fine. Just look at the minimum requirements on the games box to see if your mac can handle it, if its an older one. One thing you should be aware of is that windows runs hotter than OSX especially when playing games. So if you are using a laptop or mac mini be aware of the heat created by the CPU and GPU when playing games. These compact macs are more subject to overheating so you may want to try a fan control solution like smcfancontrol and reset the minimum fan speed before rebooting in order to keep the temps down.
